University of California San Francisco

Publications

  1. nSMase2-mediated exosome secretion shapes the tumor microenvironment to immunologically support pancreatic cancer.
    2024 | PubMed
  2. M2 Macrophage Exosomes Reverse Cardiac Functional Decline in Mice with Diet-Induced Myocardial Infarction by Suppressing Type 1 Interferon Signaling in Myeloid Cells.
    2024 | PubMed
  3. Abstract A066: nSMase2-mediated exosome secretion shapes the tumor microenvironment to immunologically support pancreatic cancer.
    2024 | UCSF Research Profile
  4. Comparison of EV characterization by commercial high-sensitivity flow cytometers and a custom single-molecule flow cytometer.
    2024 | PubMed
  5. Label-free single-vesicle based surface enhanced Raman spectroscopy: A robust approach for investigating the biomolecular composition of small extracellular vesicles.
    2024 | PubMed
  6. Abstract 3047: Extracellular Vesicles Produced By IL4-polarized Human Macrophages Suppress Atherosclerosis By Reprograming Ly6c hi Monocytes.
    2024 | UCSF Research Profile
  7. The EV antibody database: An interactive database of curated antibodies for extracellular vesicle and nanoparticle research.
    2024 | PubMed
  8. Abstract A046: nSMase2-generated ceramide promotes PDA aggression through exosome reprogramming of the stroma.
    2024 | UCSF Research Profile
  9. Polarized macrophages regulate fibro/adipogenic progenitor (FAP) adipogenesis through exosomes.
    2023 | PubMed
  10. ApoE enhances mitochondrial metabolism via microRNA-142a/146a-regulated circuits that suppress hematopoiesis and inflammation in hyperlipidemia.
    2023 | PubMed
  11. Exomap1 mouse: A transgenic model for in vivo studies of exosome biology.
    2023 | PubMed
  12. Abstract P3167: Identification Of Macrophage-specific Markers On Extracellular Vesicles In A Transgenic Mouse Model And Humans.
    2023 | UCSF Research Profile
  13. ApoE expression in macrophages communicates immunometabolic signaling that controls hyperlipidemia-driven hematopoiesis & inflammation via extracellular vesicles.
    2023 | PubMed
  14. Exomap1 mouse: a transgenic model for in vivo studies of exosome biology.
    2023 | PubMed
  15. exRNA-eCLIP intersection analysis reveals a map of extracellular RNA binding proteins and associated RNAs across major human biofluids and carriers.
    2023 | PubMed
  16. Patients with abdominal aortic aneurysms have reduced levels of microRNA 122-5p in circulating exosomes.
    2023 | PubMed
  17. Current challenges and future directions for engineering extracellular vesicles for heart, lung, blood and sleep diseases.
    2023 | PubMed
  18. MetfOrmin BenefIts Lower Extremities with Intermittent Claudication (MOBILE IC): randomized clinical trial protocol.
    2023 | PubMed
  19. Abstract C051: Ceramide signaling regulates PDA aggression through exosome reprogramming of the stroma.
    2022 | UCSF Research Profile
  20. Poster 155: Muscle-Derived Beige Adipose Precursors Secrete Promyogenic Exosomes that Treat Rotator Cuff Muscle Degeneration in Mice and are Identified in Humans by Single-Cell RNA Sequencing.
    2022 | UCSF Research Profile
  21. Phase 2 of extracellular RNA communication consortium charts next-generation approaches for extracellular RNA research.
    2022 | PubMed
  22. Muscle-Derived Beige Adipose Precursors Secrete Promyogenic Exosomes That Treat Rotator Cuff Muscle Degeneration in Mice and Are Identified in Humans by Single-Cell RNA Sequencing.
    2022 | PubMed
  23. IL-4 polarized human macrophage exosomes control cardiometabolic inflammation and diabetes in obesity.
    2022 | PubMed
  24. Visualizing transfer of microbial biomolecules by outer membrane vesicles in microbe-host-communication in vivo.
    2021 | PubMed
  25. High glucose macrophage exosomes enhance atherosclerosis by driving cellular proliferation & hematopoiesis.
    2021 | PubMed
  26. M2 macrophage exosomes regulate hematopoiesis & resolve inflammation in atherosclerosis via microrna cargo.
    2020 | UCSF Research Profile
  27. Abstract 15839: Patients With Abdominal Aortic Aneurysms Have Reduced Levels of MicroRNA 122-5p in Circulating Exosomes.
    2020 | UCSF Research Profile
  28. Abstract 17293: Hyperglycemia Enhances Pro-Inflammatory Properties of Macrophage-Derived Exosomes to Drive Hematopoiesis in Apolipoprotein E-Deficient Mouse.
    2020 | UCSF Research Profile
  29. Correction: Cushioned-Density Gradient Ultracentrifugation (C-DGUC) improves the isolation efficiency of extracellular vesicles.
    2020 | PubMed
  30. Macrophage Exosomes Resolve Atherosclerosis by Regulating Hematopoiesis and Inflammation via MicroRNA Cargo.
    2020 | PubMed
  31. Circulating exosomes from patients with peripheral artery disease influence vascular cell migration and contain distinct microRNA cargo.
    2020 | PubMed
  32. Abstract C20: Smpd3 augments chemotherapy and thwarts PDA progression.
    2019 | UCSF Research Profile
  33. Cushioned-Density Gradient Ultracentrifugation (C-DGUC) improves the isolation efficiency of extracellular vesicles.
    2019 | PubMed
  34. Female mice with apolipoprotein E4 domain interaction demonstrated impairments in spatial learning and memory performance and disruption of hippocampal cyto-architecture.
    2019 | PubMed
  35. Small RNA Sequencing across Diverse Biofluids Identifies Optimal Methods for exRNA Isolation.
    2019 | PubMed
  36. The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research.
    2019 | PubMed
  37. exRNA Atlas Analysis Reveals Distinct Extracellular RNA Cargo Types and Their Carriers Present across Human Biofluids.
    2019 | PubMed
  38. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.
    2018 | PubMed
  39. MicroRNA-146a & hematopoiesis: friend or foe in atherosclerosis.
    2018 | PubMed
  40. Apolipoprotein E and Atherosclerosis: From Lipoprotein Metabolism to MicroRNA Control of Inflammation.
    2018 | PubMed
  41. Abstract 184: Hyperglycemia Enhances Pro-inflammatory Properties of Macrophage-derived Exosomes to Drive Hematopoiesis in Apolipoprotein E-deficient Mouse.
    2018 | UCSF Research Profile
  42. Abstract 262: Circulating Exosomes from PAD Patients Modulate Vascular Repair and Inflammation.
    2018 | UCSF Research Profile
  43. Abstract 408: ApoE Regulation of Hematopoiesis Suppresses Atherosclerosis by Reducing Adaptive Immunity in Hyperlipidemic Mice.
    2018 | UCSF Research Profile
  44. Abstract 443: Cushioned-Density Gradient Ultracentrifugation (C-DGUC) Improves the Isolation Efficiency of Exosomes for their use in Atherosclerosis Research.
    2018 | UCSF Research Profile
  45. Advances, challenges, and opportunities in extracellular RNA biology: insights from the NIH exRNA Strategic Workshop.
    2018 | PubMed
  46. Cushioned-Density Gradient Ultracentrifugation (C-DGUC): A Refined and High Performance Method for the Isolation, Characterization, and Use of Exosomes.
    2018 | PubMed
  47. Isolation of Plasma Lipoproteins as a Source of Extracellular RNA.
    2018 | PubMed
  48. Therapeutic control of systemic inflammation & atherosclerosis with ApoE-polarized macrophage exosomes.
    2017 | UCSF Research Profile
  49. Hyperpolarized 13 C magnetic resonance evaluation of renal ischemia reperfusion injury in a murine model.
    2017 | PubMed
  50. An intracellular matrix metalloproteinase-2 isoform induces tubular regulated necrosis: implications for acute kidney injury.
    2017 | PubMed
  51. Extending gene ontology in the context of extracellular RNA and vesicle communication.
    2016 | PubMed
  52. Inhibition of p38 Mitogen-Activated Protein Kinase Enhances the Apoptosis Induced by Oxidized Low-Density Lipoprotein in Endothelial Progenitor Cells.
    2016 | PubMed
  53. Immunosuppression With FTY720 Reverses Cardiac Dysfunction in Hypomorphic ApoE Mice Deficient in SR-BI Expression That Survive Myocardial Infarction Caused by Coronary Atherosclerosis.
    2016 | PubMed
  54. Abstract 17311: Molecular Memory and the Epigenetic Regulation of Cardiac Intracellular Matrix Metalloproteinase-2.
    2015 | UCSF Research Profile
  55. Biogenesis, delivery, and function of extracellular RNA.
    2015 | PubMed
  56. Meeting report: discussions and preliminary findings on extracellular RNA measurement methods from laboratories in the NIH Extracellular RNA Communication Consortium.
    2015 | PubMed
  57. Apolipoprotein e e4 domain interaction in size of hippocampal subregions, density of newborn neurons, and cognitive behaviors.
    2015 | UCSF Research Profile
  58. Abstract 155: MicroRNA-146a Suppression of NF-?B-driven Monocyte/Macrophage Activation and Atherosclerosis is Regulated by Cellular ApoE Expression.
    2015 | UCSF Research Profile
  59. Abstract 23: Immunosuppression with FTY720 Reverses Cardiac Dysfunction to Prevent Chronic Heart Failure in Mice that Survive Diet-induced Myocardial Infarction.
    2015 | UCSF Research Profile
  60. Abstract 481: Diabetic Hyperglycemia Accelerates Atherosclerosis by Driving Adaptive Immunity in Mice with Similar Hyperlipidemia.
    2015 | UCSF Research Profile
  61. Apolipoprotein E enhances microRNA-146a in monocytes and macrophages to suppress nuclear factor-κB-driven inflammation and atherosclerosis.
    2015 | PubMed
  62. Apolipoprotein E and Atherosclerosis: Beyond Lipid Effects.
    2015 | UCSF Research Profile
  63. A screen in mice uncovers repression of lipoprotein lipase by microRNA-29a as a mechanism for lipid distribution away from the liver.
    2014 | PubMed
  64. The immunosuppressant FTY720 prolongs survival in a mouse model of diet-induced coronary atherosclerosis and myocardial infarction.
    2014 | PubMed
  65. Hyperglycemia impairs atherosclerosis regression in mice.
    2013 | PubMed
  66. N-terminal truncated intracellular matrix metalloproteinase-2 induces cardiomyocyte hypertrophy, inflammation and systolic heart failure.
    2013 | PubMed
  67. Inducible ApoE gene repair in hypomorphic ApoE mice deficient in the low-density lipoprotein receptor promotes atheroma stabilization with a human-like lipoprotein profile.
    2013 | PubMed
  68. Abstract 195: Apolipoprotein E Suppresses Atherosclerosis by Reducing Th1 Inflammatory Responses and by Favorably Altering Aortic Dendritic Cell Subsets in Hyperlipidemic Mice.
    2013 | UCSF Research Profile
  69. Abstract 375: Inducible ApoE Gene Repair in HypoE Mice Deficient in the LDL Receptor Promotes Atheroma Stabilization with a Human-like Lipoprotein Profile.
    2013 | UCSF Research Profile
  70. Abstract 552: The Immunosuppressant FTY720 Increases Longevity and Prevents Chronic Heart Failure in HypoE Mice Deficient in the SR-BI Receptor that Survive Myocardial Infarction Caused by Diet-induced Coronary Atherosclerosis.
    2013 | UCSF Research Profile
  71. Apolipoprotein E regulation of myeloid cell plasticity in atherosclerosis.
    2012 | PubMed
  72. Macrophage-specific apoE gene repair reduces diet-induced hyperlipidemia and atherosclerosis in hypomorphic Apoe mice.
    2012 | PubMed
  73. A novel intracellular isoform of matrix metalloproteinase-2 induced by oxidative stress activates innate immunity.
    2012 | PubMed
  74. Apolipoprotein E4 domain interaction accelerates diet-induced atherosclerosis in hypomorphic Arg-61 apoe mice.
    2012 | PubMed
  75. ApoE suppresses atherosclerosis by reducing lipid accumulation in circulating monocytes and the expression of inflammatory molecules on monocytes and vascular endothelium.
    2011 | PubMed
  76. Oxidized low-density lipoprotein induces apoptosis in endothelial progenitor cells by inactivating the phosphoinositide 3-kinase/Akt pathway.
    2010 | PubMed
  77. Apolipoprotein E Suppresses Atherosclerosis by Reducing Leukocyte Recruitment to Atheroma.
    2010 | UCSF Research Profile
  78. Heparin Protects Against Septic Mortality via Apoe-Antagonism.
    2010 | UCSF Research Profile
  79. High-density lipoprotein determines adult mouse cardiomyocyte fate after hypoxia-reoxygenation through lipoprotein-associated sphingosine 1-phosphate.
    2010 | PubMed
  80. Diet-induced occlusive coronary atherosclerosis, myocardial infarction, cardiac dysfunction, and premature death in scavenger receptor class B type I-deficient, hypomorphic apolipoprotein ER61 mice.
    2005 | PubMed
  81. VEGF is crucial for the hepatic vascular development required for lipoprotein uptake.
    2005 | PubMed
  82. Apolipoprotein E promotes the regression of atherosclerosis independently of lowering plasma cholesterol levels.
    2004 | PubMed
  83. Antibody phenotyping test for the human apolipoprotein E2 isoform.
    2003 | PubMed
  84. Cholesterol: from heart attacks to Alzheimer's disease.
    2003 | PubMed
  85. Hepatocyte-derived ApoE is more effective than non-hepatocyte-derived ApoE in remnant lipoprotein clearance.
    2003 | PubMed
  86. 3P-0878 A mouse model to study the role of ApoE in atherosclerosis regression and plaque vulnerability in peripheral arterial disease.
    2003 | UCSF Research Profile
  87. Hypomorphic apolipoprotein E mice: a new model of conditional gene repair to examine apolipoprotein E-mediated metabolism.
    2002 | PubMed
  88. Periplasmic expression and purification of recombinant Fabs.
    2002 | PubMed
  89. Introduction of human apolipoprotein E4 "domain interaction" into mouse apolipoprotein E.
    2001 | PubMed
  90. New insights into the heparan sulfate proteoglycan-binding activity of apolipoprotein E.
    2001 | PubMed
  91. Binding of an antibody mimetic of the human low density lipoprotein receptor to apolipoprotein E is governed through electrostatic forces. Studies using site-directed mutagenesis and molecular modeling.
    2000 | PubMed
  92. Bacterial expression and purification of the Fab fragment of a monoclonal antibody specific for the low-density lipoprotein receptor-binding site of human apolipoprotein E.
    1999 | PubMed
  93. Structure of a monoclonal 2E8 Fab antibody fragment specific for the low-density lipoprotein-receptor binding region of apolipoprotein E refined at 1.9 A.
    1999 | PubMed
  94. Molecular characterization of two monoclonal antibodies specific for the LDL receptor-binding site of human apolipoprotein E.
    1995 | PubMed
  95. Determination of the fine specificity and molecular cloning of two monoclonal antibodies directed against the receptor-binding domain of human apolipoprotein E.
    1994 | UCSF Research Profile