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Metabolic Regulation of Immunity in Atherosclerosis 

The Raffai laboratory explores the influence of metabolic stress on accelerated cardiovascular disease. Specifically, the laboratory's interest lies in how a protein called apolipoprotein E controls hematopoiesis through microRNAs to suppress atherosclerosis beyond lipid lowering. A second interest of the laboratory explores how hyperglycemia contributes to differential microRNA biogenesis and the subsequent release of these microRNAs into extracellular vesicles and exosomes to impact immunity. 

The laboratory addresses these questions by employing transgenic mouse models to elicit specific mechanisms of diabetes and atherosclerosis. The overarching aim is to develop new treatments for these diseases. The laboratory offers training in broad areas of atherosclerosis research ranging from fundamental lipoprotein metabolism to microRNA-controlled immunity and extracellular RNA communication.


Raffai Lab Awarded 4-Year Biomedical Laboratory Research & Development (BLRD) Grant from Veterans Health Administration

Exosomes In The Pathogenesis Of Diabetic Atherosclerosis & Its Treatment Opportunities

Recent Publications

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