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Atherosclerosis Research Lab »  Alumni »  Lab Alumni »  Nathalie Gaudreault, Ph.D.
Nathalie Gaudreault, Ph.D.

Nathalie Gaudreault, Ph.D.

Associate Director
Allen Institute for Cell Science

Contact Information

4150 Clement Street
San Francisco, CA 94121
Mail Stop: 151L
Phone: (415) 221-4810 ext. 3124
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  • Master of Science, Physiology-Endocrinology (1999), Laval University, Sainte-Foy, Quebec, Canada
  • Doctor of Philosophy, Physiology (2004), University of British Columbia, Vancouver, Canada
  • Dr. Georges Phoenix Foundation Research Fellowship (U. Laval) 1997-1998
  • St. John's College Reginald and Annie Van Fellowship (UBC) 1999-2001University Graduate Fellowship (UBC) 2000-2001
  • Heart & Stroke Foundation of B.C. & Yukon Research Fellowship 2001-2004
  • Graduate Teaching Assistant Teaching Award (UBC) 2002
  • Krogh Young Investigator Award (World Congress for Microcirculation) 2007
  • Postdoctoral Fellow, Leibniz Research Laboratories for Biotechnology and Artificial Organs, Medizinische Hochschule Hannover, Germany (2005)
  • Postdoctoral Scholar, Department of Surgery, University of California Davis Medical Center (2006-2008)
  • Vascular complications of diabetes
  • Atherosclerosis regression
  • Endothelial cell barrier function

Nathalie received a Master's degree in Physiology/Endocrinology from Laval University. Under the supervision of Dr Helene Bachelard she studied the hemodynamic effect of insulin on regional blood flow and glucose uptake in awake rats. Later, as a Heart & Stroke Foundation of B.C. & Yukon Research Trainee, she received her Ph.D. in Physiology from the University of British Columbia. During her Ph.D. in Dr. Ed Moore's Lab, Nathalie characterized glucose transport in healthy and diabetic endothelium using high resolution 3D fluorescence microscopy.

After a brief exposure to tissue engineering as a visiting scientist in the Leibniz Research Laboratories in Hannover, Germany, she took a postdoctoral position at the University of California at Davis. There, in the Laboratory of Dr Sarah Yuan she developed FRET based assays in primary endothelial cells using a genetically encoded reporter (Drs. R. Tsien and A. Newton, UCSD). She used this biosensor to measure the spatiotemporal activity and role of PKC isoforms in endothelial cell permeability. Her current research in Dr Raffai's lab focuses on the roles of macrophage/monocyte derived apolipoprotein E in the vascular wall and its involvement in atherosclerosis regression.

  1. Gaudreault N., Santure M., Pitre M., Nadeau A., Marette A., Bachelard H. (2001) Effects of insulin on regional blood flow and glucose uptake in Wistar and Sprague-Dawley rats. Metabolism. Jan;50(1):65-73.
  2. Lagaud G, Gaudreault N, Moore EDW, Van Breemen C, Laher I. (2002) Pressure-dependent myogenic constriction of cerebral arteries occurs independently of voltage-dependent activation. American Journal of Physiology (Heart Circ Physiol). Dec;283(6):H2187-95.
  3. Gaudreault N, Scriven DRL, Moore EDW. (2004) Characterisation of glucose transporters in the intact coronary artery endothelium in rats: GLUT-2 upregulated by long-term hyperglycaemia. Diabetologia. Dec;47(12):2081-92. 
  4. Gaudreault N, Scriven DRL, Moore EDW. (2006) Asymmetric subcellular distribution of glucose transporters in the endothelium of small contractile arteries. Endothelium. 13:335-342.
  5. Gaudreault N, Scriven DRL, Laher I, Moore EDW. (2008) Subcellular characterization of glucose uptake in coronary endothelial cells. Microvasc Res. Jan;75(1):73-82. Epub 2007 Apr 25.
  6. Gaudreault N, Perrin RM, Guo M, Clanton CP, Wu MH, Yuan SY. (2008) Counter regulatory effects of PKCbetaII and PKCdelta on coronary endothelial permeability. Arterioscler Thromb Vasc Biol. Aug;28(8):1527-33. Epub 2008 May 22.


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